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- Quintuplets is an American sitcom that aired twenty-two episodes on Fox from June 16, 2004 through January 12, 2005. The program starred Andy Richter and Rebecca Creskoff as parents of a family of quintuplets and their various adventures in parenthood. The series is set in Nutley, New Jersey, and is on the face of it a typical family sitcom. Much of the storyline focuses on the difficulty of supporting a large family of teens, both financially and emotionally, as they grapple with the reality that, grown up, they simply aren't as cute and interesting as they were when they were born.